Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders.

ABSTRACT: Approximately 36% of patients with neuromyelitis optica spectrum disorders (NMOSD) suffer from severe visual and motor disability (blindness or light perception or unable to walk) with abnormalities of whole-brain functional networks. However, it remains unclear how whole-brain functional networks and their dynamic properties are related to clinical disability in patients with NMOSD. Our study recruited 30 NMOSD patients (37.70 ± 11.99 years) and 45 healthy controls (HC, 41.84 ± 11.23 years). The independent component analysis, sliding-window approach and graph theory analysis were used to explore the static strength, time-varying and topological properties of large-scale functional networks and their associations with disability in NMOSD. Compared to HC, NMOSD patients showed significant

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10879085 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature