Retinal dysfunction in Huntington's disease mouse models concurs with local gliosis and microglia activation.

ABSTRACT: Huntington's disease (HD) is caused by an aberrant expansion of CAG repeats in the HTT gene that mainly affects basal ganglia. Although striatal dysfunction has been widely studied in HD mouse models, other brain areas can also be relevant to the pathology. In this sense, we have special interest on the retina as this is the most exposed part of the central nervous system that enable health monitoring of patients using noninvasive techniques. To establish the retina as an appropriate tissue for HD studies, we need to correlate the retinal alterations with those in the inner brain, i.e., striatum. We confirmed the malfunction of the transgenic R6/1 retinas, which underwent a rearrangement of their transcriptome as extensive as in the striatum. Although tissue-enriched genes were downregulat

SUBMITTER: Cano-Cano F 

PROVIDER: S-EPMC10879138 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature