Differential diagnosis of frontotemporal dementia subtypes with explainable deep learning on structural MRI.

ABSTRACT:

Background

Frontotemporal dementia (FTD) represents a collection of neurobehavioral and neurocognitive syndromes that are associated with a significant degree of clinical, pathological, and genetic heterogeneity. Such heterogeneity hinders the identification of effective biomarkers, preventing effective targeted recruitment of participants in clinical trials for developing potential interventions and treatments. In the present study, we aim to automatically differentiate patients with three clinical phenotypes of FTD, behavioral-variant FTD (bvFTD), semantic variant PPA (svPPA), and nonfluent variant PPA (nfvPPA), based on their structural MRI by training a deep neural network (DNN).

Methods

Data from 277 FTD patients (173 bvFTD, 63 nfvPPA, and 41 svPPA) recruited from two m

SUBMITTER: Ma D 

PROVIDER: S-EPMC10879283 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature