Deep learning classification for macrophage subtypes through cell migratory pattern analysis.

ABSTRACT: Macrophages can exhibit pro-inflammatory or pro-reparatory functions, contingent upon their specific activation state. This dynamic behavior empowers macrophages to engage in immune reactions and contribute to tissue homeostasis. Understanding the intricate interplay between macrophage motility and activation status provides valuable insights into the complex mechanisms that govern their diverse functions. In a recent study, we developed a classification method based on morphology, which demonstrated that movement characteristics, including speed and displacement, can serve as distinguishing factors for macrophage subtypes. In this study, we develop a deep learning model to explore the potential of classifying macrophage subtypes based solely on raw trajectory patterns. The classification

SUBMITTER: Kesapragada M 

PROVIDER: S-EPMC10879298 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature