Identification of hub genes significantly linked to temporal lobe epilepsy and apoptosis via bioinformatics analysis.

ABSTRACT:

Background

Epilepsy stands as an intricate disorder of the central nervous system, subject to the influence of diverse risk factors and a significant genetic predisposition. Within the pathogenesis of temporal lobe epilepsy (TLE), the apoptosis of neurons and glial cells in the brain assumes pivotal importance. The identification of differentially expressed apoptosis-related genes (DEARGs) emerges as a critical imperative, providing essential guidance for informed treatment decisions.

Methods

We obtained datasets related to epilepsy, specifically GSE168375 and GSE186334. Utilizing differential expression analysis, we identified a set of 249 genes exhibiting significant variations. Subsequently, through an intersection with apoptosis-related genes, we pinpointed 16 genes desi

SUBMITTER: Wang W 

PROVIDER: S-EPMC10879302 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature