The effects of respiratory rate and tidal volume on pulse pressure variation in healthy lungs-a generalized additive model approach may help overcome limitations.

ABSTRACT: Pulse pressure variation (PPV) is a well-established method for predicting fluid responsiveness in mechanically ventilated patients. The predictive accuracy is, however, disputed for ventilation with low tidal volume (V_T) or low heart-rate-to-respiratory-rate ratio (HR/RR). We investigated the effects of V_T and RR on PPV and on PPV's ability to predict fluid responsiveness. We included patients scheduled for open abdominal surgery. Prior to a 250 ml fluid bolus, we ventilated patients with combinations of V_T from 4 to 10 ml kg^-1 and RR from 10 to 31 min^-1. For each of 10 RR-V_T combinations, PPV was derived using both a classic approach and a generalized additive model (GAM) approach. The stroke volume (SV) response to fluid

SUBMITTER: Enevoldsen J 

PROVIDER: S-EPMC10879304 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature