Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson's disease.

ABSTRACT: Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson's disease (PD) patients. In a subgroup of patients, we measured selected neurotrophins, inflammatory markers and markers of oxidative stress in serum. Thirty-three PD patients with freezing of gait (FOG) were randomized to either active nVNS or sham nVNS. After baseline assessments, patients were instructed to deliver six 2  min stimulations (12  min/day) of the active nVNS/sham nVNS device for 1  month at home. Patients were then re-assessed. After a one-month washout period, they were allocat

SUBMITTER: Mondal B 

PROVIDER: S-EPMC10879328 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature