Transforming growth factor beta signaling and craniofacial development: modeling human diseases in zebrafish.

ABSTRACT: Humans and other jawed vertebrates rely heavily on their craniofacial skeleton for eating, breathing, and communicating. As such, it is vital that the elements of the craniofacial skeleton develop properly during embryogenesis to ensure a high quality of life and evolutionary fitness. Indeed, craniofacial abnormalities, including cleft palate and craniosynostosis, represent some of the most common congenital abnormalities in newborns. Like many other organ systems, the development of the craniofacial skeleton is complex, relying on specification and migration of the neural crest, patterning of the pharyngeal arches, and morphogenesis of each skeletal element into its final form. These processes must be carefully coordinated and integrated. One way this is achieved is through the spatial an

SUBMITTER: Fox SC 

PROVIDER: S-EPMC10879340 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature