Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis.

ABSTRACT: Atherosclerosis is a complex vascular disorder characterized by the deposition of lipids, inflammatory cascades, and plaque formation in arterial walls. A thorough understanding of its causes and progression is necessary to develop effective diagnostic and therapeutic strategies. Recent breakthroughs in metabolomics have provided valuable insights into the molecular mechanisms and genetic factors involved in atherosclerosis, leading to innovative approaches for preventing and treating the disease. In our study, we analyzed clinical serum samples from both atherosclerosis patients and animal models using laser desorption ionization mass spectrometry. By employing methods such as orthogonal partial least-squares discrimination analysis (OPLS-DA), heatmaps, and volcano plots, we can accuratel

SUBMITTER: Ma S 

PROVIDER: S-EPMC10879346 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature