Restoring GABA_B receptor expression in the ventral tegmental area of methamphetamine addicted mice inhibits locomotor sensitization and drug seeking behavior.

ABSTRACT: Repeated exposure to psychostimulants such as methamphetamine (METH) induces neuronal adaptations in the mesocorticolimbic dopamine system, including the ventral tegmental area (VTA). These changes lead to persistently enhanced neuronal activity causing increased dopamine release and addictive phenotypes. A factor contributing to increased dopaminergic activity in this system appears to be reduced GABA_B receptor-mediated neuronal inhibition in the VTA. Dephosphorylation of serine 783 (Ser783) of the GABA_B2 subunit by protein phosphatase 2A (PP2A) appears to trigger the downregulation GABA_B receptors in psychostimulant-addicted rodents. Therefore, preventing the interaction of GABA_B receptors with PP2A using an interfer

SUBMITTER: Hleihil M 

PROVIDER: S-EPMC10879384 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature