A systematic review and meta-analysis of proteomic and metabolomic alterations in anaphylaxis reactions.

ABSTRACT:

Background

Anaphylaxis manifests as a severe immediate-type hypersensitivity reaction initiated through the immunological activation of target B-cells by allergens, leading to the release of mediators. However, the well-known underlying pathological mechanisms do not fully explain the whole variety of clinical and immunological presentations. We performed a systemic review of proteomic and metabolomic studies and analyzed the extracted data to improve our understanding and identify potential new biomarkers of anaphylaxis.

Methods

Proteomic and metabolomic studies in both human subjects and experimental models were extracted and selected through a systematic search conducted on databases such as PubMed, Scopus, and Web of Science, up to May 2023.

Results

Of 137 retriev

SUBMITTER: Gallizzi AA 

PROVIDER: S-EPMC10879545 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature