Immune cell infiltrates in peritoneal metastases from colorectal cancer.

ABSTRACT:

Background

The presence of peritoneal metastases (PMs) in patients with colorectal cancer (CRC) confers a poor prognosis and only a minority of patients will benefit from the available treatment options. In primary CRC tumors, it is well established that a high infiltration of CD8⁺ effector T cells correlates to a favorable patient outcome. In contrast, the immune response induced in PMs from CRC and how it relates to patient survival is still unknown. In this study, we characterized the immune infiltrates and the distribution of immune checkpoint receptors on T cells from PMs from CRC, in order to evaluate the potential benefit of checkpoint blockade immunotherapy for this patient group.

Methods

Surgically resected PM tissue from CRC patients (n=22) and sy

SUBMITTER: Sundstrom P 

PROVIDER: S-EPMC10879551 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature