No evidence for a causal link between Helicobacter pylori infection and Irritable bowel syndrome: a Mendelian randomization study.

ABSTRACT:

Background

Although clinical studies have revealed a potential link between Helicobacter pylori (H. pylori) infection and irritable bowel syndrome (IBS), the causal relationship between them remains unknown. The objective of this study was to investigate whether H. pylori infection is causally associated with IBS.

Method

A two-sample Mendelian randomization (MR) analysis using the inverse variance weighted (IVW), weighted mode, weighted median and MR-Egger methods was performed. We used the publicly available summary statistics data sets of genome-wide association studies (GWAS) for H. pylori infection in individuals of European descent (case = 1,058, control = 3,625) as the exposure and a GWAS for non-cancer illness code self-reported: IBS (case

SUBMITTER: Wang C 

PROVIDER: S-EPMC10879563 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature