T follicular helper cells expansion in transplant recipients correlates with graft infiltration and adverse outcomes.

ABSTRACT:

Introduction

The process of immunization following vaccination in humans bears similarities to that of immunization with allografts. Whereas vaccination aims to elicit a rapid response, in the transplant recipient, immunosuppressants slow the immunization to alloantigens. The induction of CD4+CXCR5+ T follicular helper (Tfh) cells has been shown to correlate with the success of vaccine immunization.

Method

We studied a cohort of 65 transplant recipients who underwent histological evaluation concurrent with PBMC isolation and follow-up sampling to investigate the phenotypic profiles in the blood and allotissue and analyze their association with clinical events.

Results

The proportion of circulating Tfh cells was heterogeneous over time. Patients in whom this compartmen

SUBMITTER: Desy O 

PROVIDER: S-EPMC10879567 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature