Major cardiovascular events under biologic psoriasis therapies: a 19-year real-world analysis of FAERS data.

ABSTRACT:

Objective

Over the years when biologic psoriasis therapies (TNF inhibitors, IL-12/23 inhibitors, IL-23 inhibitors, and IL-17 inhibitors) have been used in psoriasis patients, reports of major cardiovascular events (MACEs) have emerged. This study aims to investigate the association between MACEs and biologic psoriasis therapies by using information reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods

FAERS data (January 2004 to December 2022) were reviewed. For each drug-event pair, the proportional reporting ratio (PRR) and the multi-item gamma Poisson shrinker (MGPS) algorithms were used to identify drug-adverse event associations.

Results

We filtered the query for indication and identified 173,330 reports with psoriasis in

SUBMITTER: Ding L 

PROVIDER: S-EPMC10879569 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature