A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes.

ABSTRACT:

Introduction

Data on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.

Methods

We performed a genome wide association study (GWAS) to identify genes associated with survival/mortality, relapse, and severe graft-versus-host disease (sGvHD), fitting proportional hazard and subdistributional models to data of n=1,392 recipients of European ancestry from three centres.

Results

The single nucleotide polymorphism (SNP) rs17154454, intronic to the neuronal growth guidant semaphorin 3C gene (SEMA3C), was genome-wide significantly associated with event-free survival (p=7.0x10^-8) and sGvHD (p=7.5x10^-8). Further associations were detected for SNPs in the Paxillin gene (PXN)

SUBMITTER: Rosenberger A 

PROVIDER: S-EPMC10879589 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature