Gut resistome profiling reveals high diversity and fluctuations in pancreatic cancer cohorts.

ABSTRACT:

Background

Pancreatic cancer is one of the deadliest cancer, with a 5-year overall survival rate of 11%. Unfortunately, most patients are diagnosed with advanced stage by the time they present with symptoms. In the past decade, microbiome studies have explored the association of pancreatic cancer with the human oral and gut microbiomes. However, the gut microbial antibiotic resistance genes profiling of pancreatic cancer patients was never reported compared to that of the healthy cohort.

Results

In this study, we addressed the gut microbial antibiotic resistance genes profile using the metagenomic data from two online public pancreatic cancer cohorts. We found a high degree of data concordance between the two cohorts, which can therefore be used for cross-sectional compariso

SUBMITTER: Liu X 

PROVIDER: S-EPMC10879602 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature