Relative effectiveness of bivalent COVID-19 vaccine: a systematic review and meta-analysis.

ABSTRACT:

Objective

The rapid development of COVID-19 bivalent vaccines (BVs) has encompassed both the original virus strains and the variant strain. However, the effectiveness of BVs is largely unknown. Therefore, we conducted a systematic review and meta-analysis of the effectiveness of BVs.

Methods

Literature research was conducted through PubMed, Cochrane Library, Embase, and Web of Science up until November 4, 2023. Both randomized control trials and observational studies were considered for inclusion. Pooled estimates were calculated using a random effects model. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias in cohort and case-control studies.

Results

A total of 1,174 articles were reviewed and 22 eligible studies were included. All included studies

SUBMITTER: Cheng MQ 

PROVIDER: S-EPMC10879625 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature