Bleeding events in thrombotic antiphospholipid syndrome: prevalence, severity, and associated damage accrual.

ABSTRACT:

Background

Life-long anticoagulation increases bleeding risk in patients with antiphospholipid syndrome (APS). The Damage Index for Antiphospholipid Syndrome does not include bleeding events in damage accrual.

Objectives

We aimed to characterize the prevalence, severity, and damage associated with bleeding events in patients with APS.

Methods

This was a single-center retrospective analysis of patients with thrombotic APS (2006 Sydney criteria). Bleeding events were reviewed up to 43 years and classified according to the ISTH definitions into 2 groups: 1) major bleedings and 2) nonmajor bleedings (minor bleedings and clinically relevant nonmajor bleedings). Damage events were recorded as bleeding events a) resulting in permanent (>6 months) decrease in organ function a

SUBMITTER: Gaspar P 

PROVIDER: S-EPMC10879794 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature