Applying a modified systematic review and integrated assessment framework (SYRINA) - a case study on triphenyl phosphate.

ABSTRACT: This work presents a case study in applying a systematic review framework (SYRINA) to the identification of chemicals as endocrine disruptors. The suitability and performance of the framework is tested with regard to the widely accepted World Health Organization definition of an endocrine disruptor (ED). The endocrine disrupting potential of triphenyl phosphate (TPP), a well-studied flame retardant reported to exhibit various endocrine related effects was assessed. We followed the 7 steps of the SYRINA framework, articulating the research objective via Populations, Exposures, Comparators, Outcomes (PECO) statements, performed literature search and screening, conducted study evaluation, performed data extraction and summarized and integrated the evidence. Overall, 66 studies, consist

SUBMITTER: Bui TT 

PROVIDER: S-EPMC10879963 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature