A novel nomogram to predict the overall survival of early-stage hepatocellular carcinoma patients following ablation therapy.

ABSTRACT:

Introduction

This study aimed to assess factors affecting the prognosis of early-stage hepatocellular carcinoma (HCC) patients undergoing ablation therapy and create a nomogram for predicting their 3-, 5-, and 8-year overall survival (OS).

Methods

The research included 881 early-stage HCC patients treated at Beijing You'an Hospital, affiliated with Capital Medical University, from 2014 to 2022. A nomogram was developed using independent prognostic factors identified by Lasso and multivariate Cox regression analyses. Its predictive performance was evaluated with concordance index (C-index), receiver operating characteristic curve (ROC), calibration curve, and decision curve analysis (DCA).

Results

The study identified age, tumor number, tumor size, gamma-glutamyl trans

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10880021 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature