Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects.

ABSTRACT:

Background

Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein not previously described in the human central nervous system (CNS).

Objectives

We determined MFAP4 CNS expression and measured cerebrospinal fluid (CSF) and serum levels.

Methods

Tissue was sampled at autopsy from patients with acute multiple sclerosis (MS) (n = 3), progressive MS (n = 3), neuromyelitis optica spectrum disorder (NMOSD) (n = 2), and controls (n = 9), including 6 healthy controls (HC). MFAP4 levels were measured in 152 patients: 49 MS, 62 NMOSD, 22 myelin oligodendrocyte glycoprotein-associated disease (MOGAD), and 19 isolated optic neuritis (ION).

Results

MFAP4 localized to meninges and vascular/perivascular spaces, intense in th

SUBMITTER: Samadzadeh S 

PROVIDER: S-EPMC10880047 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature