Causal associations between modifiable risk factors and isolated REM sleep behavior disorder: a mendelian randomization study.

ABSTRACT:

Objectives

This Mendelian randomization (MR) study identified modifiable risk factors for isolated rapid eye movement sleep behavior disorder (iRBD).

Methods

Genome-wide association study (GWAS) datasets for 29 modifiable risk factors for iRBD in discovery and replication stages were used. GWAS data for iRBD cases were obtained from the International RBD Study Group. The inverse variance weighted (IVW) method was primarily employed to explore causality, with supplementary analyses used to verify the robustness of IVW findings. Co-localization analysis further substantiated causal associations identified via MR. Genetic correlations between mental illness and iRBD were identified using trait covariance, linkage disequilibrium score regression, and co-localization analyses.

SUBMITTER: Zhang RY 

PROVIDER: S-EPMC10880103 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature