Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity.

ABSTRACT:

Aims

Alleviating neurological dysfunction caused by acute ischemic stroke (AIS) remains intractable. Given Annexin A6 (ANXA6)'s potential in promoting axon branching and repairing cell membranes, the study aimed to explore ANXA6's potential in alleviating AIS-induced neurological dysfunction.

Methods

A mouse middle cerebral artery occlusion model was established. Brain and plasma ANXA6 levels were detected at different timepoints post ischemia/reperfusion (I/R). We overexpressed and down-regulated brain ANXA6 and evaluated infarction volume, neurological function, and synaptic plasticity-related proteins post I/R. Plasma ANXA6 levels were measured in patients with AIS and healthy controls, investigating ANXA6 expression's clinical significance.

Results

Brain ANXA6 lev

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10880127 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature