α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Ca_v3.2 calcium signaling in astrocytes.

ABSTRACT:

Background

It is now realized that Parkinson's disease (PD) pathology extends beyond the substantia nigra, affecting both central and peripheral nervous systems, and exhibits a variety of non-motor symptoms often preceding motor features. Neuroinflammation induced by activated microglia and astrocytes is thought to underlie these manifestations. α-Synuclein aggregation has been linked with sustained neuroinflammation in PD, aggravating neuronal degeneration; however, there is still a lack of critical information about the structural identity of the α-synuclein conformers that activate microglia and/or astrocytes and the molecular pathways involved.

Methods

To investigate the role of α-synuclein conformers in the development and maintenance of neuroinflammation, we used prima

SUBMITTER: Leandrou E 

PROVIDER: S-EPMC10880263 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature