TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions.

ABSTRACT:

Background

Calcium is a ubiquitous intracellular messenger that regulates the expression of various genes involved in cell proliferation, differentiation, and motility. The involvement of calcium in diverse metabolic pathways has been suggested. However, the effect of calcium in peroxisomes, which are involved in fatty acid oxidation and scavenges the result reactive oxygen species (ROS), remains elusive. In addition, impaired peroxisomal ROS inhibit the mammalian target of rapamycin complex 1 (mTORC1) and promote autophagy. Under stress, autophagy serves as a protective mechanism to avoid cell death. In response to oxidative stress, lysosomal calcium mediates transcription factor EB (TFEB) activation. However, the impact of calcium on peroxisome function and the mechanisms governi

SUBMITTER: Manandhar L 

PROVIDER: S-EPMC10880274 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature