Comparative efficacy and safety of COVID-19 vaccines in phase III trials: a network meta-analysis.

ABSTRACT:

Background

Over a dozen vaccines are in or have completed phase III trials at an unprecedented speed since the World Health Organization (WHO) declared COVID-19 a pandemic. In this review, we aimed to compare and rank these vaccines indirectly in terms of efficacy and safety using a network meta-analysis.

Methods

We searched Embase, MEDLINE, and the Cochrane Library for phase III randomized controlled trials (RCTs) from their inception to September 30, 2023. Two investigators independently selected articles, extracted data, and assessed the risk of bias. Outcomes included efficacy in preventing symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the incidence of serious adverse events (SAEs) according to vaccine type and individual vaccines

SUBMITTER: Wu X 

PROVIDER: S-EPMC10880292 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature