Microfluidic compartmentalization of rat vagal afferent neurons to model gut-brain axis.

ABSTRACT:

Background

Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are important for detecting and relaying sensory information from the periphery to the central nervous system to modulate feeding behavior, metabolism, and inflammation. Confounding variables complicate the process of isolating the role of the vagal afferents in mediating these physiological processes. Therefore, we developed a microfluidic model of the sensory branch of the gut-brain axis. We show that this microfluidic model successfully compartmentalizes the cell body and neurite terminals of the neurons, thereby simulates the anatomical layout of these neurons to more accur

SUBMITTER: Girardi G 

PROVIDER: S-EPMC10880301 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature