Pro-inflammatory cerebrospinal fluid profile of neonates with intraventricular hemorrhage: clinical relevance and contrast with CNS infection.

ABSTRACT:

Background

Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningitis) promote pro-inflammatory CSF conditions reflected in CSF parameters.

Methods

Biochemical and cytological profiles of lumbar CSF and peripheral blood samples were analyzed for 81 control, 29 IVH grade 1/2 (IVH_1/2), 13 IVH grade 3/4 (IVH_3/4), 15 PHH, 20 culture-confirmed bacterial meningitis (BM), and 27 viral meningitis (VM) infants at 36.5 ± 4 weeks estimated gestational age.

Results

PHH infants had higher (p < 0.02) CSF total cell and red blood cell (RBC) counts compared to control, IVH_1/2, BM, and VM infants. No di

SUBMITTER: Garcia-Bonilla M 

PROVIDER: S-EPMC10880312 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature