Safety, feasibility, and impact on the gut microbiome of kefir administration in critically ill adults.

ABSTRACT:

Background

Dysbiosis of the gut microbiome is frequent in the intensive care unit (ICU), potentially leading to a heightened risk of nosocomial infections. Enhancing the gut microbiome has been proposed as a strategic approach to mitigate potential adverse outcomes. While prior research on select probiotic supplements has not successfully shown to improve gut microbial diversity, fermented foods offer a promising alternative. In this open-label phase I safety and feasibility study, we examined the safety and feasibility of kefir as an initial step towards utilizing fermented foods to mitigate gut dysbiosis in critically ill patients.

Methods

We administered kefir in escalating doses (60 mL, followed by 120 mL after 12 h, then 240 mL daily) to 54 critically ill patients with

SUBMITTER: Gupta VK 

PROVIDER: S-EPMC10880344 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature