Causal relationships of metabolites with allergic diseases: a trans-ethnic Mendelian randomization study.

ABSTRACT:

Background

Allergic diseases exert a considerable impact on global health, thus necessitating investigations into their etiology and pathophysiology for devising effective prevention and treatment strategies. This study employs a Mendelian randomization (MR) analysis and meta-analysis to identify metabolite targets potentially associated with allergic diseases.

Methods

A two-sample MR analysis was conducted to explore potential causal relationships between circulating and urinary metabolites and allergic diseases. Exposures were derived from a genome-wide association study (GWAS) of 486 circulating metabolites and a GWAS of 55 targeted urinary metabolites. Outcome data for allergic diseases, including atopic dermatitis (AD), allergic rhinitis (AR), and asthma, were obtained

SUBMITTER: Tu J 

PROVIDER: S-EPMC10880354 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature