Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age.

ABSTRACT:

Background

Previous studies of singletons evaluating prenatal phthalate exposure and early neurodevelopment reported mixed results and the associations could be biased by parental, obstetrical, and genetic factors.

Methods

A co-twin control design was employed to test whether prenatal phthalate exposure was associated with children's neurocognitive development. We collected information from 97 mother-twin pairs enrolled in the Wuhan Twin Birth Cohort between March 2016 and October 2018. Fourteen phthalate metabolites were measured in maternal urine collected at each trimester. Neurodevelopmental differences in twins at the age of two were examined as the outcome of interest. Multiple informant model was used to examine the covariate-adjusted associations of prenatal phthalat

SUBMITTER: Xiao H 

PROVIDER: S-EPMC10880363 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature