Effects of Shenmai injection against chronic heart failure: a meta-analysis and systematic review of preclinical and clinical studies.

ABSTRACT: Objective: This study aims to evaluate the clinical and preclinical efficacy of SMI in treating CHF, and to summarize the relevant mechanisms of action in order to provide evidence for its role in CHF treatment. Methods: A systematic computerized search of eight databases and three registry systems was performed, with the time frame spanning from the inception of the databases to 30 June 2023. Strict procedures were used for data extraction, quality assessment, and data analysis. The methodological quality of the included studies was assessed using RoB-2 and SYRCLE tools. Statistical analysis was performed using Rev Man 5.4 software, using either fixed-effects or random-effects models. Results: A total of 25 clinical trials (including test group 1,367 patients, control

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10880451 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature