Understanding clinical and biological heterogeneity to advance precision medicine in paediatric acute respiratory distress syndrome.

ABSTRACT: Paediatric acute respiratory distress syndrome (PARDS) is a heterogeneous clinical syndrome that is associated with high rates of mortality and long-term morbidity. Factors that distinguish PARDS from adult acute respiratory distress syndrome (ARDS) include changes in developmental stage and lung maturation with age, precipitating factors, and comorbidities. No specific treatment is available for PARDS and management is largely supportive, but methods to identify patients who would benefit from specific ventilation strategies or ancillary treatments, such as prone positioning, are needed. Understanding of the clinical and biological heterogeneity of PARDS, and of differences in clinical features and clinical course, pathobiology, response to treatment, and outcomes between PARDS and adult

SUBMITTER: Kneyber MCJ 

PROVIDER: S-EPMC10880453 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature