Effects of unstable β-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2.

ABSTRACT: Amino acyl-tRNA synthetases perform diverse non-canonical functions aside from their essential role in charging tRNAs with their cognate amino acid. The phenylalanyl-tRNA synthetase (PheRS/FARS) is an α₂β₂ tetramer that is needed for charging the tRNA^Phe for its translation activity. Fragments of the α-subunit have been shown to display an additional, translation-independent, function that activates growth and proliferation and counteracts Notch signalling. Here we show in Drosophila that overexpressing the β-subunit in the context of the complete PheRS leads to larval roaming, food avoidance, slow growth, and a developmental delay that can last several days and even prevents pupation. These behavioural and developmental phenotypes are induced by Phe

SUBMITTER: Brunßen D 

PROVIDER: S-EPMC10880493 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature