Dietary resistant starch supplementation increases gut luminal deoxycholic acid abundance in mice.

ABSTRACT: Bile acids (BA) are among the most abundant metabolites produced by the gut microbiome. Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into secondary BAs, which can differentially regulate host health via signaling based on their varying affinity for BA receptors. Despite the importance of secondary BAs in host health, the regulation of 7-α-dehydroxylation and the role of diet in modulating this process is incompletely defined. Understanding this process could lead to dietary guidelines that beneficially shift BA metabolism. Dietary fiber regulates gut microbial composition and metabolite production. We tested the hypothesis that feeding mice a diet rich in a fermentable dietary fiber, resistant starch (RS), would alter gut bacterial BA metabolism. Mal

SUBMITTER: Reuter MA 

PROVIDER: S-EPMC10880513 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature