Probing efficient microbial CO₂ utilisation through metabolic and process modelling.

ABSTRACT: Acetogenic gas fermentation is increasingly studied as a promising technology to upcycle carbon-rich waste gasses. Currently the product range is limited, and production yields, rates and titres for a number of interesting products do not allow for economically viable processes. By pairing process modelling and host-agnostic metabolic modelling, we compare fermentation conditions and various products to optimise the processes. The models were then used in a simulation of an industrial-scale bubble column reactor. We find that increased temperatures favour gas transfer rates, particularly for the valuable and limiting H₂ , while furthermore predicting an optimal feed composition of 9:1 mol H₂ to mol CO₂ . Metabolically, the increased non-growth associated ma

SUBMITTER: Gorter de Vries PJ 

PROVIDER: S-EPMC10880515 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature