The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study.

ABSTRACT:

Background

Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines.

Objectives

We studied drug-survival of low dose of thioguanine in real-life clinical practice in comparison to conventional thiopurines.

Design

Retrospective observational study.

Methods

All patients born 1956 and later, and who at least once started thiopurine treatment between 2006 and 2022 were included. A medical chart review was performed that noted drug-survival for every thiopurine treatment attempt. The Mantel-Cox rank test was used to test differences in drug-survival for different thiopurines. Blood chemistry analysis and faecal calprotectin leve

SUBMITTER: Gensmyr-Singer H 

PROVIDER: S-EPMC10880529 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature