Association between postoperative ibuprofen exposure and acute kidney injury after pediatric cardiac surgery.

ABSTRACT:

Background

Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery and is associated with worse outcomes. Ibuprofen is widely used in the perioperative period and can affect kidney function in children. However, the association between ibuprofen exposure and AKI after pediatric cardiac surgery has not been determined yet.

Methods

In this retrospective cohort study, children undergoing cardiac surgery with cardiopulmonary bypass were studied. Exposure was defined as given ibuprofen in the first 7 days after surgery. Postoperative AKI was diagnosed using the KDIGO criteria. A multivariable Cox regression model was used to assess the association between ibuprofen exposure and postoperative AKI by taking ibuprofen as a time-varying covariate.

Result

SUBMITTER: Shi S 

PROVIDER: S-EPMC10880564 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature