Ecology- and genome-based identification of the Bifidobacterium adolescentis prototype of the healthy human gut microbiota.

ABSTRACT: Bifidobacteria are among the first microbial colonizers of the human gut, being frequently associated with human health-promoting activities. In the current study, an in silico methodology based on an ecological and phylogenomic-driven approach allowed the selection of a Bifidobacterium adolescentis prototype strain, i.e., B. adolescentis PRL2023, which best represents the overall genetic content and functional features of the B. adolescentis taxon. Such features were confirmed by in vitro experiments aimed at evaluating the ability of this strain to survive in the gastrointestinal tract of the host and its ability to interact with human intestinal cells and other microbial gut commensals. In this context, co-cultivation of B. adolescentis PRL2023

SUBMITTER: Argentini C 

PROVIDER: S-EPMC10880601 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature