A new ROS response factor YvmB protects Bacillus licheniformis against oxidative stress under adverse environment.

ABSTRACT: Bacillus spp., a class of aerobic bacteria, is widely used as a biocontrol microbe in the world. However, the reactive oxygen species (ROS) will accumulate once the aerobic bacteria are exposed to environmental stresses, which can decrease cell activity or lead to cell death. Hydroxyl radical (·OH), the strongest oxide in the ROS, can damage DNA directly, which is generated through Fenton Reaction by H₂O₂ and free iron. Here, we proved that the synthesis of pulcherriminic acid (PA), an iron chelator produced by Bacillus spp., could reduce DNA damage to protect cells from oxidative stress by sequestrating excess free iron, which enhanced the cell survival rates in stressful conditions (salt, antibiotic, and high temperature). It was worth noting that the

SUBMITTER: He P 

PROVIDER: S-EPMC10880666 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature