Nebulon: a system for the inference of functional relationships of gene products from the rearrangement of predicted operons.

ABSTRACT: Since operons are unstable across Prokaryotes, it has been suggested that perhaps they re-combine in a conservative manner. Thus, genes belonging to a given operon in one genome might re-associate in other genomes revealing functional relationships among gene products. We developed a system to build networks of functional relationships of gene products based on their organization into operons in any available genome. The operon predictions are based on inter-genic distances. Our system can use different kinds of thresholds to accept a functional relationship, either related to the prediction of operons, or to the number of non-redundant genomes that support the associations. We also work by shells, meaning that we decide on the number of linking iterations to allow for the complementation

SUBMITTER: Janga SC 

PROVIDER: S-EPMC1088069 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature