Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication.

ABSTRACT: The borders between cell and developmental biology, which have always been permeable, have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and developmental approaches (increasingly complemented by human genetics, structural insights, and computational analysis) fruitfully advancing understanding of this fascinating, multifunctional organelle. The last eukaryotic common ancestor probably possessed a motile cilium, providing evolution with ample opportunity to adapt cilia to many jobs. Over the last decades, we have learned how non-motile, primary cilia play important roles in intercellular communication. Reflecting their diverse motility and signaling functions, compromised cilia cause a diverse range of diseases collectively called "ciliopathies." In thi

SUBMITTER: Derderian C 

PROVIDER: S-EPMC10880727 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature