TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting.

ABSTRACT: Genome-wide genealogies of multiple species carry detailed information about demographic and selection processes on individual branches of the phylogeny. Here, we introduce TRAILS, a hidden Markov model that accurately infers time-resolved population genetics parameters, such as ancestral effective population sizes and speciation times, for ancestral branches using a multi-species alignment of three species and an outgroup. TRAILS leverages the information contained in incomplete lineage sorting fragments by modelling genealogies along the genome as rooted three-leaved trees, each with a topology and two coalescent events happening in discretized time intervals within the phylogeny. Posterior decoding of the hidden Markov model can be used to infer the ancestral recombination graph for the

SUBMITTER: Rivas-Gonzalez I 

PROVIDER: S-EPMC10880969 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature