Distribution modeling quantifies collective T_H cell decision circuits in chronic inflammation.

ABSTRACT: Immune responses are tightly regulated by a diverse set of interacting immune cell populations. Alongside decision-making processes such as differentiation into specific effector cell types, immune cells initiate proliferation at the beginning of an inflammation, forming two layers of complexity. Here, we developed a general mathematical framework for the data-driven analysis of collective immune cell dynamics. We identified qualitative and quantitative properties of generic network motifs, and we specified differentiation dynamics by analysis of kinetic transcriptome data. Furthermore, we derived a specific, data-driven mathematical model for T helper 1 versus T follicular helper cell-fate decision dynamics in acute and chronic lymphocytic choriomeningitis virus infections in mice. The mo

SUBMITTER: Burt P 

PROVIDER: S-EPMC10881075 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature