High frequency oscillation network dynamics predict outcome in non-palliative epilepsy surgery.

ABSTRACT: High frequency oscillations are a promising biomarker of outcome in intractable epilepsy. Prior high frequency oscillation work focused on counting high frequency oscillations on individual channels, and it is still unclear how to translate those results into clinical care. We show that high frequency oscillations arise as network discharges that have valuable properties as predictive biomarkers. Here, we develop a tool to predict patient outcome before surgical resection is performed, based on only prospective information. In addition to determining high frequency oscillation rate on every channel, we performed a correlational analysis to evaluate the functional connectivity of high frequency oscillations in 28 patients with intracranial electrodes. We found that high frequency oscillatio

SUBMITTER: Lin J 

PROVIDER: S-EPMC10881100 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature