Divergent evolutionary rates of primate brain regions as revealed by genomics and transcriptomics.

ABSTRACT: Although the primate brain contains numerous functionally distinct structures that have experienced diverse genetic changes during the course of evolution and development, these changes remain to be explored in detail. Here we utilize two classic metrics from evolutionary biology, the evolutionary rate index (ERI) and the transcriptome age index (TAI), to investigate the evolutionary alterations that have occurred in each area and developmental stage of the primate brain. We observed a higher evolutionary rate for those genes expressed in the non-cortical areas during primate evolution, particularly in human, with the highest rate of evolution being exhibited at brain developmental stages between late infancy and early childhood. Further, the transcriptome age of the non-cortical areas was

SUBMITTER: Zhuang XL 

PROVIDER: S-EPMC10881106 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature