Effect of nabiximols oromucosal spray (Sativex^®) on symptoms associated with multiple sclerosis-related spasticity: a case series.

ABSTRACT: Spasticity and its related symptoms of spasms, pain, sleep disturbance and bladder dysfunction are common in persons with multiple sclerosis (MS) and may be interconnected through a common pathophysiology and/or may trigger and worsen each other. Tetrahydrocannabinol-cannabidiol (nabiximols) oromucosal spray (Sativex) is an add-on treatment for adults with moderate-to-severe MS spasticity who fail to respond adequately to conventional oral medications. There is evidence that nabiximols can ameliorate spasticity-associated symptoms irrespective of its effect on spasticity. This case series describes 12 adults with MS spasticity who were evaluated for symptom evolution before and during adjunctive nabiximols treatment. Nabiximols reduced spasticity severity in 11 patients, of whom 8 had a cl

SUBMITTER: Garde N 

PROVIDER: S-EPMC10881112 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature