Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy.

ABSTRACT:

Background

Epilepsy is a common neurological disease; however, few if any of the currently marketed antiseizure medications prevent or cure epilepsy. Discovery of pathological processes in the early stages of epileptogenesis has been challenging given the common use of preclinical models that induce seizures in physiologically normal animals. Moreover, despite known sex dimorphism in neurological diseases, females are rarely included in preclinical epilepsy models.

Methods

We characterized sex differences in mice carrying a pathogenic knockin variant (p.N1768D) in the Scn8a gene that causes spontaneous tonic-clonic seizures (TCs) at ∼3 months of age and found that heterozygous females are more resilient than males in mortality and morbidity. To investigate the cellular mecha

SUBMITTER: Hammer MF 

PROVIDER: S-EPMC10881277 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature