Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment.

ABSTRACT:

Background

Neuromyelitis optica spectrum disorder (NMOSD) associated with cognitive impairment (CI) is acknowledged. However, the underlying pathogenesis and involvement of the immune system remain unclear.

Objectives

This study aimed to investigate the alterations in immune cells, cytokines, and GABA⁺ levels in NMOSD patients with cognitive deficits.

Methods

Thirty-eight NMOSD patients and 38 healthy controls (HCs) were included. NMOSD patients were stratified as NMOSD-CI and NMOSD-CP groups. The difference in cognitive functions, Tfh and cytokines, and GABA⁺ levels were assessed, and their correlations were calculated.

Results

NMOSD-CI patients showed worse performance on all cognitive tests, and the percentage of circulating follicular

SUBMITTER: Duan Y 

PROVIDER: S-EPMC10881283 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature